1d2n

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[[Image:1d2n.gif|left|200px]]
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{{Structure
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|PDB= 1d2n |SIZE=350|CAPTION= <scene name='initialview01'>1d2n</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1d2n", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1d2n| PDB=1d2n | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2n OCA], [http://www.ebi.ac.uk/pdbsum/1d2n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d2n RCSB]</span>
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'''D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN'''
'''D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN'''
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Whiteheart, S W.]]
[[Category: Whiteheart, S W.]]
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[[Category: atpase]]
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[[Category: Atpase]]
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[[Category: hexamerization domain]]
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[[Category: Hexamerization domain]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:22:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:33:21 2008''
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Revision as of 10:22, 2 May 2008

Image:1d2n.gif

Template:STRUCTURE 1d2n

D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN


Overview

N-ethylmaleimide-sensitive fusion protein (NSF) is a cytosolic ATPase required for many intracellular vesicle fusion reactions. NSF consists of an amino-terminal region that interacts with other components of the vesicle trafficking machinery, followed by two homologous ATP-binding cassettes, designated D1 and D2, that possess essential ATPase and hexamerization activities, respectively. The crystal structure of D2 bound to Mg2+-AMPPNP has been determined at 1.75 A resolution. The structure consists of a nucleotide-binding and a helical domain, and it is unexpectedly similar to the first two domains of the clamp-loading subunit delta' of E. coli DNA polymerase III. The structure suggests several regions responsible for coupling of ATP hydrolysis to structural changes in full-length NSF.

About this Structure

1D2N is a Single protein structure of sequence from Cricetulus griseus. The following page contains interesting information on the relation of 1D2N with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein., Lenzen CU, Steinmann D, Whiteheart SW, Weis WI, Cell. 1998 Aug 21;94(4):525-36. PMID:9727495 Page seeded by OCA on Fri May 2 13:22:48 2008

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