1d2m

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2m OCA], [http://www.ebi.ac.uk/pdbsum/1d2m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d2m RCSB]</span>
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'''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''
'''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sugahara, M.]]
[[Category: Sugahara, M.]]
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[[Category: multidomain protein]]
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[[Category: Multidomain protein]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:22:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:33:24 2008''
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Revision as of 10:22, 2 May 2008

Image:1d2m.jpg

Template:STRUCTURE 1d2m

UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME


Overview

In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.

About this Structure

1D2M is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:10578047 Page seeded by OCA on Fri May 2 13:22:48 2008

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