1d76

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[[Image:1d76.gif|left|200px]]
[[Image:1d76.gif|left|200px]]
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{{Structure
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|PDB= 1d76 |SIZE=350|CAPTION= <scene name='initialview01'>1d76</scene>, resolution 1.300&Aring;
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The line below this paragraph, containing "STRUCTURE_1d76", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1AP:2,6-DIAMINOPURINE+NUCLEOTIDE'>1AP</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1d76| PDB=1d76 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d76 OCA], [http://www.ebi.ac.uk/pdbsum/1d76 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d76 RCSB]</span>
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'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''
'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''
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==About this Structure==
==About this Structure==
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1D76 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D76 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D76 OCA].
==Reference==
==Reference==
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1390739 1390739]
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1390739 1390739]
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[[Category: Protein complex]]
 
[[Category: Berman, H M.]]
[[Category: Berman, H M.]]
[[Category: Gaffney, B.]]
[[Category: Gaffney, B.]]
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[[Category: Jones, R.]]
[[Category: Jones, R.]]
[[Category: Schneider, B.]]
[[Category: Schneider, B.]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: modified]]
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[[Category: Modified]]
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[[Category: z-dna]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:31:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:36:00 2008''
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Revision as of 10:31, 2 May 2008

Image:1d76.gif

Template:STRUCTURE 1d76

CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS


Overview

The crystal and molecular structure of d(CGUA'CG)2 (where A' is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 A. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., & Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:1390739 Page seeded by OCA on Fri May 2 13:31:28 2008

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