2w2s

From Proteopedia

(Difference between revisions)

Revision as of 20:51, 19 September 2018

Structure of the Lagos bat virus matrix protein

Structural highlights

2w2s is a 1 chain structure with sequence from Lbv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2w2r
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MATRX_LBV] Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype New Jersey (genus: Vesiculovirus) and from Lagos bat virus (genus: Lyssavirus), revealing that both share a common fold despite sharing no identifiable sequence homology. Strikingly, in both structures a stretch of residues from the otherwise-disordered N terminus of a crystallographically adjacent molecule is observed binding to a hydrophobic cavity on the surface of the protein, thereby forming non-covalent linear polymers of M in the crystals. While the overall topology of the interaction is conserved between the two structures, the molecular details of the interactions are completely different. The observed interactions provide a compelling model for the flexible self-assembly of the matrix protein during virion morphogenesis and may also modulate interactions with host proteins.

Rhabdovirus matrix protein structures reveal a novel mode of self-association.,Graham SC, Assenberg R, Delmas O, Verma A, Gholami A, Talbi C, Owens RJ, Stuart DI, Grimes JM, Bourhy H PLoS Pathog. 2008 Dec;4(12):e1000251. Epub 2008 Dec 26. PMID:19112510^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Graham SC, Assenberg R, Delmas O, Verma A, Gholami A, Talbi C, Owens RJ, Stuart DI, Grimes JM, Bourhy H. Rhabdovirus matrix protein structures reveal a novel mode of self-association. PLoS Pathog. 2008 Dec;4(12):e1000251. Epub 2008 Dec 26. PMID:19112510 doi:10.1371/journal.ppat.1000251

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w2s"

@@ Line 1: / Line 1: @@
-==STRUCTURE OF THE LAGOS BAT VIRUS MATRIX PROTEIN==
+==Structure of the Lagos bat virus matrix protein==
 <StructureSection load='2w2s' size='340' side='right' caption='[[2w2s]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2w2s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lbv Lbv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W2S FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w2r|2w2r]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2s OCA], [http://pdbe.org/2w2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w2s RCSB], [http://www.ebi.ac.uk/pdbsum/2w2s PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2s OCA], [http://pdbe.org/2w2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w2s RCSB], [http://www.ebi.ac.uk/pdbsum/2w2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2s ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2s_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

2w2s

From Proteopedia

Revision as of 20:51, 19 September 2018

Structure of the Lagos bat virus matrix protein

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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