1d8m

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[[Image:1d8m.gif|left|200px]]
[[Image:1d8m.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1d8m |SIZE=350|CAPTION= <scene name='initialview01'>1d8m</scene>, resolution 2.44&Aring;
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The line below this paragraph, containing "STRUCTURE_1d8m", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BBH:1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC+ACID+HYDROXYAMIDE'>BBH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1d8m| PDB=1d8m | SCENE= }}
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|RELATEDENTRY=[[1cqr|1CQR]], [[1d5j|1D5J]], [[1d7x|1D7X]], [[1d8f|1D8F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8m OCA], [http://www.ebi.ac.uk/pdbsum/1d8m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d8m RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR'''
'''CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR'''
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[[Category: Taiwo, Y O.]]
[[Category: Taiwo, Y O.]]
[[Category: Williams, L E.]]
[[Category: Williams, L E.]]
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[[Category: inhibited]]
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[[Category: Inhibited]]
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[[Category: mixed alpha beta structure]]
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[[Category: Mixed alpha beta structure]]
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[[Category: zinc protease]]
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[[Category: Zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:34:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:36:50 2008''
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Revision as of 10:34, 2 May 2008

Image:1d8m.gif

Template:STRUCTURE 1d8m

CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR


Overview

Potent and selective inhibition of matrix metalloproteinases was demonstrated for a series of sulfonamide-based hydroxamic acids. The design of the heterocyclic sulfonamides incorporates a six- or seven-member central ring with a P2' substituent that can be modified. Binding interactions of this substituent at the S2' site are believed to contribute to high inhibitory potency against stromelysin, collagenase-3 and gelatinases A and B, and to provide selectivity against collagenase-1 and matrilysin. An X-ray structure of a stromelysin inhibitor complex was obtained to provide insights into the SAR and selectivity trends observed for the series.

About this Structure

1D8M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Heterocycle-based MMP inhibitors with P2' substituents., Pikul S, Dunham KM, Almstead NG, De B, Natchus MG, Taiwo YO, Williams LE, Hynd BA, Hsieh LC, Janusz MJ, Gu F, Mieling GE, Bioorg Med Chem Lett. 2001 Apr 23;11(8):1009-13. PMID:11327577 Page seeded by OCA on Fri May 2 13:34:29 2008

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