1d9e

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[[Image:1d9e.jpg|left|200px]]
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{{Structure
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|PDB= 1d9e |SIZE=350|CAPTION= <scene name='initialview01'>1d9e</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1d9e", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span>
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{{STRUCTURE_1d9e| PDB=1d9e | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9e OCA], [http://www.ebi.ac.uk/pdbsum/1d9e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d9e RCSB]</span>
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'''STRUCTURE OF E. COLI KDO8P SYNTHASE'''
'''STRUCTURE OF E. COLI KDO8P SYNTHASE'''
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[[Category: Radaev, S.]]
[[Category: Radaev, S.]]
[[Category: Woodard, R W.]]
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[[Category: a5p]]
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[[Category: A5p]]
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[[Category: dah7p]]
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[[Category: Dah7p]]
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[[Category: kdo]]
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[[Category: Kdo]]
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[[Category: kdo8p]]
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[[Category: Kdo8p]]
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[[Category: pep]]
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[[Category: Pep]]
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Revision as of 10:35, 2 May 2008

Image:1d9e.jpg

Template:STRUCTURE 1d9e

STRUCTURE OF E. COLI KDO8P SYNTHASE


Overview

3-deoxy-D-manno-octulosonate 8-phosphate (KDO8P) synthase catalyzes the condensation of phosphoenolpyruvate (PEP) with arabinose 5-phosphate (A5P) to form KDO8P and inorganic phosphate. KDO8P is the phosphorylated precursor of 3-deoxy-D-manno-octulosonate, an essential sugar of the lipopolysaccharide of Gram-negative bacteria. The crystal structure of the Escherichia coli KDO8P synthase has been determined by multiple wavelength anomalous diffraction and the model has been refined to 2.4 A (R-factor, 19.9%; R-free, 23.9%). KDO8P synthase is a homotetramer in which each monomer has the fold of a (beta/alpha)(8) barrel. On the basis of the features of the active site, PEP and A5P are predicted to bind with their phosphate moieties 13 A apart such that KDO8P synthesis would proceed via a linear intermediate. A reaction similar to KDO8P synthesis, the condensation of phosphoenolpyruvate, and erythrose 4-phosphate to form 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P), is catalyzed by DAH7P synthase. In the active site of DAH7P synthase the two substrates PEP and erythrose 4-phosphate appear to bind in a configuration similar to that proposed for PEP and A5P in the active site of KDO8P synthase. This observation suggests that KDO8P synthase and DAH7P synthase evolved from a common ancestor and that they adopt the same catalytic strategy.

About this Structure

1D9E is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase., Radaev S, Dastidar P, Patel M, Woodard RW, Gatti DL, J Biol Chem. 2000 Mar 31;275(13):9476-84. PMID:10734095 Page seeded by OCA on Fri May 2 13:35:45 2008

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