1da1

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[[Image:1da1.gif|left|200px]]
[[Image:1da1.gif|left|200px]]
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{{Structure
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|PDB= 1da1 |SIZE=350|CAPTION= <scene name='initialview01'>1da1</scene>, resolution 2.250&Aring;
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The line below this paragraph, containing "STRUCTURE_1da1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1da1| PDB=1da1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1da1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da1 OCA], [http://www.ebi.ac.uk/pdbsum/1da1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1da1 RCSB]</span>
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'''STRUCTURAL CHARACTERISATION OF THE BROMOURACIL-GUANINE BASE PAIR MISMATCH IN A Z-DNA FRAGMENT'''
'''STRUCTURAL CHARACTERISATION OF THE BROMOURACIL-GUANINE BASE PAIR MISMATCH IN A Z-DNA FRAGMENT'''
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==About this Structure==
==About this Structure==
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1DA1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA1 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA1 OCA].
==Reference==
==Reference==
Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment., Brown T, Kneale G, Hunter WN, Kennard O, Nucleic Acids Res. 1986 Feb 25;14(4):1801-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3951996 3951996]
Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment., Brown T, Kneale G, Hunter WN, Kennard O, Nucleic Acids Res. 1986 Feb 25;14(4):1801-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3951996 3951996]
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[[Category: Protein complex]]
 
[[Category: Brown, T.]]
[[Category: Brown, T.]]
[[Category: Hunter, W N.]]
[[Category: Hunter, W N.]]
[[Category: Kennard, O.]]
[[Category: Kennard, O.]]
[[Category: Kneale, G.]]
[[Category: Kneale, G.]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: mismatched]]
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[[Category: Mismatched]]
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[[Category: modified]]
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[[Category: Modified]]
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[[Category: z-dna]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:37:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:39 2008''
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Revision as of 10:37, 2 May 2008

Image:1da1.gif

Template:STRUCTURE 1da1

STRUCTURAL CHARACTERISATION OF THE BROMOURACIL-GUANINE BASE PAIR MISMATCH IN A Z-DNA FRAGMENT


Overview

The deoxyoligonucleotide d(BrU-G-C-G-C-G) was crystallised at pH 8.2 and its structure analysed by X-ray diffraction. The unit cell, of dimensions a = 17.94, b = 30.85, c = 49.94A contains four DNA duplexes in space group P2(1)2(1)2(1). The duplexes are in the Z conformation, with four Watson-Crick G.C base pairs and two BrU.G base pairs. The structure was refined to an R factor of 0.16 at a resolution of 2.2A with 64 solvent molecules located. The BrU.G base pair mismatch is of the wobble type, with both bases in the major tautomer form and hydrogen bonds linking 0-2 of BrU with N-1 of G and N3 of BrU with 0-6 of G. There is no indication of the presence of ionised base pairs, in spite of the high pH of crystallisation. The results are discussed in terms of the mutagenic properties of 5- bromouracil.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment., Brown T, Kneale G, Hunter WN, Kennard O, Nucleic Acids Res. 1986 Feb 25;14(4):1801-9. PMID:3951996 Page seeded by OCA on Fri May 2 13:37:04 2008

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