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3gvo

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Revision as of 07:14, 1 November 2017

Structure and RNA binding of the mouse Pumilio-2 Puf Domain

Structural highlights

3gvo is a 1 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3gvt
Gene:	Pum2 (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PUM2_MOUSE] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Puf proteins control translation through the interaction of a C-terminal Puf domain with specific sequences present in the 3' untranslated region of messenger RNAs. In Drosophila, binding of the protein Pumilio to mRNA leads to translational repression which is required for anterior/posterior patterning during embryogenesis. The vertebrate Pumilio homologue 2 (Pum2) has been implicated in controlling germ cell development through interactions with the RNA binding proteins deleted in azoospermia (DAZ), DAZ-like (DAZL) and BOULE. We present the 1.6A resolution X-ray crystal structure of the Puf domain from murine Pum2 and demonstrate that this domain is capable of binding with nanomolar affinity to RNA sequences from the hunchback Nanos response element (NRE) and a previously identified Pum2 binding element (PBE).

Structure and RNA binding of the mouse Pumilio-2 Puf domain.,Jenkins HT, Baker-Wilding R, Edwards TA J Struct Biol. 2009 Sep;167(3):271-6. Epub 2009 Jun 18. PMID:19540345^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jenkins HT, Baker-Wilding R, Edwards TA. Structure and RNA binding of the mouse Pumilio-2 Puf domain. J Struct Biol. 2009 Sep;167(3):271-6. Epub 2009 Jun 18. PMID:19540345 doi:10.1016/j.jsb.2009.06.007

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gvo"

@@ Line 1: / Line 1: @@
 ==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==
 <StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gvt|3gvt]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://pdbe.org/3gvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://pdbe.org/3gvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>
 </table>
 == Function ==

3gvo

From Proteopedia

Revision as of 07:14, 1 November 2017

Structure and RNA binding of the mouse Pumilio-2 Puf Domain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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