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1ddp

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[[Image:1ddp.gif|left|200px]]
[[Image:1ddp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ddp |SIZE=350|CAPTION= <scene name='initialview01'>1ddp</scene>
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The line below this paragraph, containing "STRUCTURE_1ddp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CPT:CIS-PLATINUM-(NH3)2'>CPT</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ddp| PDB=1ddp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddp OCA], [http://www.ebi.ac.uk/pdbsum/1ddp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ddp RCSB]</span>
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}}
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'''SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK'''
'''SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK'''
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==About this Structure==
==About this Structure==
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1DDP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDP OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDP OCA].
==Reference==
==Reference==
Solution structure of a cisplatin-induced DNA interstrand cross-link., Huang H, Zhu L, Reid BR, Drobny GP, Hopkins PB, Science. 1995 Dec 15;270(5243):1842-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525382 8525382]
Solution structure of a cisplatin-induced DNA interstrand cross-link., Huang H, Zhu L, Reid BR, Drobny GP, Hopkins PB, Science. 1995 Dec 15;270(5243):1842-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525382 8525382]
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[[Category: Protein complex]]
 
[[Category: Drobny, G P.]]
[[Category: Drobny, G P.]]
[[Category: Hopkins, P B.]]
[[Category: Hopkins, P B.]]
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[[Category: Reid, B R.]]
[[Category: Reid, B R.]]
[[Category: Zhu, L.]]
[[Category: Zhu, L.]]
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[[Category: antitumor drug]]
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[[Category: Antitumor drug]]
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[[Category: cis-ddp]]
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[[Category: Cis-ddp]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: interstrand cross-link]]
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[[Category: Interstrand cross-link]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:35 2008''
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Revision as of 10:44, 2 May 2008

Image:1ddp.gif

Template:STRUCTURE 1ddp

SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK


Overview

The widely used antitumor drug cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. The solution structure of the short duplex [d(CAT-AGCTATG)]2 cross-linked at the GC:GC site was determined by nuclear magnetic resonance (NMR). The deoxyguanosine-bridging cis-diammineplatinum(II) lies in the minor groove, and the complementary deoxycytidines are extrahelical. The double helix is locally reversed to a left-handed form, and the helix is unwound and bent toward the minor groove. These findings were independently confirmed by results from a phase-sensitive gel electrophoresis bending assay. The NMR structure differs markedly from previously proposed models but accounts for the chemical reactivity, the unwinding, and the bending of cis-DDP interstrand cross-linked DNA and may be important in the formation and repair of these cross-links in chromatin.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of a cisplatin-induced DNA interstrand cross-link., Huang H, Zhu L, Reid BR, Drobny GP, Hopkins PB, Science. 1995 Dec 15;270(5243):1842-5. PMID:8525382 Page seeded by OCA on Fri May 2 13:44:08 2008

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