1ddx

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[[Image:1ddx.gif|left|200px]]
[[Image:1ddx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ddx |SIZE=350|CAPTION= <scene name='initialview01'>1ddx</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1ddx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGX:7-[6-(3-HYDROPEROXY-OCT-1-ENYL)-2,3-DIOXA-BICYCLO[2.2.1]HEPT-5-YL]-HEPT-5-ENOIC+ACID'>PGX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ddx| PDB=1ddx | SCENE= }}
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|RELATEDENTRY=[[1cvu|1CVU]], [[1dcx|1DCX]], [[1dd0|1DD0]], [[6cox|6COX]], [[5cox|5COX]], [[1cqe|1CQE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddx OCA], [http://www.ebi.ac.uk/pdbsum/1ddx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ddx RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE'''
'''CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE'''
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[[Category: Stegeman, R A.]]
[[Category: Stegeman, R A.]]
[[Category: Stevens, A M.]]
[[Category: Stevens, A M.]]
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[[Category: arachidonate]]
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[[Category: Arachidonate]]
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[[Category: cox-2]]
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[[Category: Cox-2]]
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[[Category: cyclooxygenase]]
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[[Category: Cyclooxygenase]]
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[[Category: endoperoxide]]
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[[Category: Endoperoxide]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: prostaglandin]]
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[[Category: Prostaglandin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:39 2008''
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Revision as of 10:44, 2 May 2008

Image:1ddx.gif

Template:STRUCTURE 1ddx

CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE


Overview

Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids. The two known cyclooxygenases isoforms share a high degree of amino-acid sequence similarity, structural topology and an identical catalytic mechanism. Cyclooxygenase enzymes catalyse two sequential reactions in spatially distinct, but mechanistically coupled active sites. The initial cyclooxygenase reaction converts arachidonic acid (which is achiral) to prostaglandin G2 (which has five chiral centres). The subsequent peroxidase reaction reduces prostaglandin G2 to prostaglandin H2. Here we report the co-crystal structures of murine apo-cyclooxygenase-2 in complex with arachidonic acid and prostaglandin. These structures suggest the molecular basis for the stereospecificity of prostaglandin G2 synthesis.

About this Structure

1DDX is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the stereochemistry of the cyclooxygenase reaction., Kiefer JR, Pawlitz JL, Moreland KT, Stegeman RA, Hood WF, Gierse JK, Stevens AM, Goodwin DC, Rowlinson SW, Marnett LJ, Stallings WC, Kurumbail RG, Nature. 2000 May 4;405(6782):97-101. PMID:10811226 Page seeded by OCA on Fri May 2 13:44:30 2008

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