1ddw

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[[Image:1ddw.gif|left|200px]]
[[Image:1ddw.gif|left|200px]]
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{{Structure
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|PDB= 1ddw |SIZE=350|CAPTION= <scene name='initialview01'>1ddw</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1ddw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|ACTIVITY=
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{{STRUCTURE_1ddw| PDB=1ddw | SCENE= }}
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|RELATEDENTRY=[[1ddv|1DDV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddw OCA], [http://www.ebi.ac.uk/pdbsum/1ddw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ddw RCSB]</span>
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'''HOMER EVH1 DOMAIN UNLIGANDED'''
'''HOMER EVH1 DOMAIN UNLIGANDED'''
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[[Category: Worley, P F.]]
[[Category: Worley, P F.]]
[[Category: Xiao, B.]]
[[Category: Xiao, B.]]
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[[Category: pleckstrin homology domain fold]]
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[[Category: Pleckstrin homology domain fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:43 2008''
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Revision as of 10:44, 2 May 2008

Image:1ddw.gif

Template:STRUCTURE 1ddw

HOMER EVH1 DOMAIN UNLIGANDED


Overview

Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact. This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes.

About this Structure

1DDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition., Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ, Neuron. 2000 Apr;26(1):143-54. PMID:10798399 Page seeded by OCA on Fri May 2 13:44:30 2008

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