1den

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1den FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1den OCA], [http://www.ebi.ac.uk/pdbsum/1den PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1den RCSB]</span>
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'''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''
'''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''
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[[Category: Foray, M F.]]
[[Category: Foray, M F.]]
[[Category: Lancelin, J M.]]
[[Category: Lancelin, J M.]]
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[[Category: venom(potassium channel inhibitor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:46:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:40:08 2008''
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Revision as of 10:46, 2 May 2008

Image:1den.gif

Template:STRUCTURE 1den

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS


Overview

We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of < 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.

About this Structure

1DEN is a Single protein structure of sequence from Dendroaspis polylepis polylepis. Full crystallographic information is available from OCA.

Reference

Proteinase inhibitor homologues as potassium channel blockers., Lancelin JM, Foray MF, Poncin M, Hollecker M, Marion D, Nat Struct Biol. 1994 Apr;1(4):246-50. PMID:7544683 Page seeded by OCA on Fri May 2 13:46:03 2008

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