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==Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease==
==Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease==
<StructureSection load='2q3k' size='340' side='right' caption='[[2q3k]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2q3k' size='340' side='right' caption='[[2q3k]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MUW:N-{(5S)-5-[{[4-(AMINOMETHYL)PHENYL]SULFONYL}(ISOBUTYL)AMINO]-6-HYDROXYHEXYL}-NALPHA-(METHOXYCARBONYL)-BETA-PHENYL-L-PHENYLALANINAMIDE'>MUW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MUW:N-{(5S)-5-[{[4-(AMINOMETHYL)PHENYL]SULFONYL}(ISOBUTYL)AMINO]-6-HYDROXYHEXYL}-NALPHA-(METHOXYCARBONYL)-BETA-PHENYL-L-PHENYLALANINAMIDE'>MUW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3k OCA], [http://pdbe.org/2q3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q3k RCSB], [http://www.ebi.ac.uk/pdbsum/2q3k PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3k OCA], [http://pdbe.org/2q3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q3k RCSB], [http://www.ebi.ac.uk/pdbsum/2q3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3k ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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</div>
</div>
<div class="pdbe-citations 2q3k" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2q3k" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Immunodeficiency virus protease|Immunodeficiency virus protease]]
== References ==
== References ==
<references/>
<references/>

Revision as of 09:38, 18 October 2017

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease

2q3k, resolution 2.00Å

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