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1dl0
From Proteopedia
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[[Image:1dl0.gif|left|200px]] | [[Image:1dl0.gif|left|200px]] | ||
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'''SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C''' | '''SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DL0 is a [[Single protein]] structure | + | 1DL0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: King, G F.]] | [[Category: King, G F.]] | ||
[[Category: Wang, X H.]] | [[Category: Wang, X H.]] | ||
| - | [[Category: | + | [[Category: Atracotoxin]] |
| - | [[Category: | + | [[Category: Cystine knot]] |
| - | [[Category: | + | [[Category: Insecticidal]] |
| - | [[Category: | + | [[Category: Neurotoxin]] |
| - | [[Category: | + | [[Category: Vicinal disulfide]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:58:20 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:58, 2 May 2008
SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C
Overview
We have isolated a family of insect-selective neurotoxins from the venom of the Australian funnel-web spider that appear to be good candidates for biopesticide engineering. These peptides, which we have named the Janus-faced atracotoxins (J-ACTXs), each contain 36 or 37 residues, with four disulfide bridges, and they show no homology to any sequences in the protein/DNA databases. The three-dimensional structure of one of these toxins reveals an extremely rare vicinal disulfide bridge that we demonstrate to be critical for insecticidal activity. We propose that J-ACTX comprises an ancestral protein fold that we refer to as the disulfide-directed beta-hairpin.
About this Structure
1DL0 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge., Wang X, Connor M, Smith R, Maciejewski MW, Howden ME, Nicholson GM, Christie MJ, King GF, Nat Struct Biol. 2000 Jun;7(6):505-13. PMID:10881200 Page seeded by OCA on Fri May 2 13:58:20 2008
