1dlz
From Proteopedia
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| - | + | {{STRUCTURE_1dlz| PDB=1dlz | SCENE= }} | |
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'''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)''' | '''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLZ OCA]. | |
==Reference== | ==Reference== | ||
NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10682854 10682854] | NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10682854 10682854] | ||
| - | [[Category: Emericellopsis salmosynnemata]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Arseniev, A S.]] | [[Category: Arseniev, A S.]] | ||
[[Category: Balashova, T A.]] | [[Category: Balashova, T A.]] | ||
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[[Category: Shenkarev, Z O.]] | [[Category: Shenkarev, Z O.]] | ||
[[Category: Tagaev, A A.]] | [[Category: Tagaev, A A.]] | ||
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Bent helix]] |
| - | [[Category: | + | [[Category: Channel-former]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: Peptaibol]] |
| - | [[Category: | + | [[Category: Zervamicin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:00:11 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:00, 2 May 2008
SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)
Overview
Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of different polarity ranging from CDCl3/CD3OH (9:1, v/v) to CD3OH/H2O (1:1, v/v). The results show that in all solvents used the peptide has a very similar structure that is a bent amphiphilic helix with a mean backbone root mean square deviation (rmsd) value of ca. 0.3 A. Side chains of Trp1, Ile2, Gln3, Ile5 and Thr6 are mobile. The results are discussed in relation to the validity of the obtained structure to serve as a building block of zervamicin IIB ion channels.
About this Structure
Full crystallographic information is available from OCA.
Reference
NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:10682854 Page seeded by OCA on Fri May 2 14:00:11 2008
