1dn0

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[[Image:1dn0.gif|left|200px]]
[[Image:1dn0.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dn0 OCA], [http://www.ebi.ac.uk/pdbsum/1dn0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dn0 RCSB]</span>
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'''STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ'''
'''STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ'''
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[[Category: Leoni, J.]]
[[Category: Leoni, J.]]
[[Category: Polikarpov, I.]]
[[Category: Polikarpov, I.]]
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[[Category: antibody]]
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[[Category: Antibody]]
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[[Category: cold agglutinin]]
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[[Category: Cold agglutinin]]
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[[Category: fab]]
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[[Category: Fab]]
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[[Category: human]]
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[[Category: Human]]
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[[Category: igm]]
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[[Category: Igm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:46 2008''
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Revision as of 11:02, 2 May 2008

Image:1dn0.gif

Template:STRUCTURE 1dn0

STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ


Overview

Cold agglutinins (CAs) are IgM autoantibodies characterized by their ability to agglutinate in vitro RBC at low temperatures. These autoantibodies cause hemolytic anemia in patients with CA disease. Many diverse Ags are recognized by CAs, most frequently those belonging to the I/i system. These are oligosaccharides composed of repeated units of N:-acetyllactosamine, expressed on RBC. The three-dimensional structure of the Fab of KAU, a human monoclonal IgM CA with anti-I activity, was determined. The KAU combining site shows an extended cavity and a neighboring pocket. Residues from the hypervariable loops V(H)CDR3, V(L)CDR1, and V(L)CDR3 form the cavity, whereas the small pocket is defined essentially by residues from the hypervariable loops V(H)CDR1 and V(H)CDR2. This fact could explain the V(H)4-34 germline gene restriction among CA. The KAU combining site topography is consistent with one that binds a polysaccharide. The combining site overall dimensions are 15 A wide and 24 A long. Conservation of key binding site residues among anti-I/i CAs indicates that this is a common feature of this family of autoantibodies. We also describe the first high resolution structure of the human IgM C(H)1:C(L) domain. The structural analysis shows that the C(H)1-C(L) interface is mainly conserved during the isotype switch process from IgM to IgG1.

About this Structure

1DN0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the Fab from a human IgM cold agglutinin., Cauerhff A, Braden BC, Carvalho JG, Aparicio R, Polikarpov I, Leoni J, Goldbaum FA, J Immunol. 2000 Dec 1;165(11):6422-8. PMID:11086081 Page seeded by OCA on Fri May 2 14:02:31 2008

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