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1dnc

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[[Image:1dnc.gif|left|200px]]
[[Image:1dnc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dnc |SIZE=350|CAPTION= <scene name='initialview01'>1dnc</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1dnc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GTT:GLUTATHIONE'>GTT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1dnc| PDB=1dnc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dnc OCA], [http://www.ebi.ac.uk/pdbsum/1dnc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dnc RCSB]</span>
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}}
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'''HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON'''
'''HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON'''
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[[Category: Savvides, S N.]]
[[Category: Savvides, S N.]]
[[Category: Schirmer, R H.]]
[[Category: Schirmer, R H.]]
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[[Category: nitric oxide]]
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[[Category: Nitric oxide]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: sulfhydryl oxidation]]
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[[Category: Sulfhydryl oxidation]]
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[[Category: sulfinic acid]]
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[[Category: Sulfinic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:03:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:52 2008''
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Revision as of 11:03, 2 May 2008

Image:1dnc.gif

Template:STRUCTURE 1dnc

HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON


Overview

Nitric oxide (NO) is a pluripotent regulatory molecule, yet the molecular mechanisms by which it exerts its effects are largely unknown. Few physiologic target molecules of NO have been identified, and even for these, the modifications caused by NO remain uncharacterized. Human glutathione reductase (hGR), a central enzyme of cellular antioxidant defense, is inhibited by S-nitrosoglutathione (GSNO) and by diglutathionyl-dinitroso-iron (DNIC-[GSH]2), two in vivo transport forms of NO. Here, crystal structures of hGR inactivated by GSNO and DNIC-[GSH]2 at 1.7 A resolution provide the first picture of enzyme inactivation by NO-carriers: in GSNO-modified hGR, the active site residue Cys 63 is oxidized to an unusually stable cysteine sulfenic acid (R-SOH), whereas modification with DNIC-[GSH]2 oxidizes Cys 63 to a cysteine sulfinic acid (R-SO2H). Our results illustrate that various forms of NO can mediate distinct chemistry, and that sulfhydryl oxidation must be considered as a major mechanism of NO action.

About this Structure

1DNC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers., Becker K, Savvides SN, Keese M, Schirmer RH, Karplus PA, Nat Struct Biol. 1998 Apr;5(4):267-71. PMID:9546215 Page seeded by OCA on Fri May 2 14:03:15 2008

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