1dnm

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[[Image:1dnm.gif|left|200px]]
[[Image:1dnm.gif|left|200px]]
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{{Structure
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|PDB= 1dnm |SIZE=350|CAPTION= <scene name='initialview01'>1dnm</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_1dnm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1dnm| PDB=1dnm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dnm OCA], [http://www.ebi.ac.uk/pdbsum/1dnm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dnm RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''
'''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''
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==About this Structure==
==About this Structure==
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1DNM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNM OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNM OCA].
==Reference==
==Reference==
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2395870 2395870]
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2395870 2395870]
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[[Category: Protein complex]]
 
[[Category: Li, B F.]]
[[Category: Li, B F.]]
[[Category: Neidle, S.]]
[[Category: Neidle, S.]]
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[[Category: Tickle, I J.]]
[[Category: Tickle, I J.]]
[[Category: Webster, G D.]]
[[Category: Webster, G D.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: mismatched]]
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[[Category: Mismatched]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:03:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:45:00 2008''
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Revision as of 11:03, 2 May 2008

Image:1dnm.gif

Template:STRUCTURE 1dnm

CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)


Overview

The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:2395870 Page seeded by OCA on Fri May 2 14:03:21 2008

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