1dok

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[[Image:1dok.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1dok", creates the "Structure Box" on the page.
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{{STRUCTURE_1dok| PDB=1dok | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dok OCA], [http://www.ebi.ac.uk/pdbsum/1dok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dok RCSB]</span>
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'''MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM'''
'''MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM'''
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[[Category: Lubkowski, J.]]
[[Category: Lubkowski, J.]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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[[Category: chemoattractant]]
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[[Category: Chemoattractant]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: x-ray structure]]
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[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:05:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:45:37 2008''
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Revision as of 11:05, 2 May 2008

Image:1dok.gif

Template:STRUCTURE 1dok

MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM


Overview

The X-ray crystal structure of recombinant human monocyte chemoattractant protein (MCP-1) has been solved in two crystal forms. One crystal form (P), refined to 1.85 A resolution, contains a dimer in the asymmetric unit, while the other (I) contains a monomer and was refined at 2.4 A. Although both crystal forms grow together in the same droplet, the respective quaternary structures of the protein differ dramatically. In addition, both X-ray structures differ to a similar extent from the solution structure of MCP-1. Such extent of variability of quaternary structures is unprecedented. In the crystal structures, the well-ordered N termini of MCP-1 form 3(10)-helices. Comparison of the three MCP-1 structures revealed a direct correlation between the main-chain conformation of the first two cysteine residues and the quaternary arrangements. These data can be used to explain the structural basis for the assignment of residues responsible for biological activity.

About this Structure

1DOK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions., Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A, Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326 Page seeded by OCA on Fri May 2 14:05:23 2008

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