1dp4

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[[Image:1dp4.gif|left|200px]]
[[Image:1dp4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dp4 |SIZE=350|CAPTION= <scene name='initialview01'>1dp4</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1dp4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1dp4| PDB=1dp4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp4 OCA], [http://www.ebi.ac.uk/pdbsum/1dp4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dp4 RCSB]</span>
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}}
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'''DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR'''
'''DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR'''
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[[Category: Yee, V C.]]
[[Category: Yee, V C.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: periplasmic binding protein fold]]
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[[Category: Periplasmic binding protein fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:45:54 2008''
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Revision as of 11:06, 2 May 2008

Image:1dp4.gif

Template:STRUCTURE 1dp4

DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR


Overview

The atrial natriuretic peptide (ANP) hormone is secreted by the heart in response to an increase in blood pressure. ANP exhibits several potent anti-hypertensive actions in the kidney, adrenal gland and vascular system. These actions are induced by hormone binding extracellularly to the ANP receptor, thereby activating its intracellular guanylyl cyclase domain for the production of cyclic GMP. Here we present the crystal structure of the glycosylated dimerized hormone-binding domain of the ANP receptor at 2.0-A resolution. The monomer comprises two interconnected subdomains, each encompassing a central beta-sheet flanked by alpha-helices, and exhibits the type I periplasmic binding protein fold. Dimerization is mediated by the juxtaposition of four parallel helices, arranged two by two, which brings the two protruding carboxy termini into close relative proximity. From affinity labelling and mutagenesis studies, the ANP-binding site maps to the side of the dimer crevice and extends to near the dimer interface. A conserved chloride-binding site is located in the membrane distal domain, and we found that hormone binding is chloride dependent. These studies suggest mechanisms for hormone activation and the allostery of the ANP receptor.

About this Structure

1DP4 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor., van den Akker F, Zhang X, Miyagi M, Huo X, Misono KS, Yee VC, Nature. 2000 Jul 6;406(6791):101-4. PMID:10894551 Page seeded by OCA on Fri May 2 14:06:17 2008

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