This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Thymidine kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_1e2j| PDB=1e2j | SIZE=350| SCENE= |right| CAPTION=Human thymidine kinase dimer complex with thymidine (stick model) and sulfate, [[1e2j]] }}
{{STRUCTURE_1e2j| PDB=1e2j | SIZE=350| SCENE= |right| CAPTION=Human thymidine kinase dimer complex with thymidine (stick model) and sulfate, [[1e2j]] }}
 +
== Function ==
 +
'''Thymidine kinase''' (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. '''TK1''' is cell cycle-dependent while '''TK2''' <ref>PMID:18459168</ref>is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK. For more details see [[Herpes Simplex Virus Thymidine Kinase]].
-
'''Thymidine kinase''' (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. '''TK1''' is cell cycle-dependent while '''TK2''' is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK. For more details see [[Herpes Simplex Virus Thymidine Kinase]].
+
== Relevance ==
 +
TK1 level in serum is a marker for leukemia and lymphoma<ref>PMID:16142366</ref>.
== 3D Structures of thymidine kinase ==
== 3D Structures of thymidine kinase ==
Line 62: Line 65:
**[[1w4r]] – hTK2 + TTP
**[[1w4r]] – hTK2 + TTP
}}
}}
-
 
+
== References ==
 +
<references/>

Revision as of 06:24, 14 September 2016

Template:STRUCTURE 1e2j

Contents

Function

Thymidine kinase (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. TK1 is cell cycle-dependent while TK2 [1]is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK. For more details see Herpes Simplex Virus Thymidine Kinase.

Relevance

TK1 level in serum is a marker for leukemia and lymphoma[2].

3D Structures of thymidine kinase

Updated on 14-September-2016

References

  1. ↑ Perez-Perez MJ, Priego EM, Hernandez AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future. Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. PMID:18459168 doi:http://dx.doi.org/10.1002/med.20124
  2. ↑ He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S. Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep. 2005 Oct;14(4):1013-9. PMID:16142366

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Thymidine_kinase"
Personal tools