1dvp

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[[Image:1dvp.gif|left|200px]]
[[Image:1dvp.gif|left|200px]]
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{{Structure
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|PDB= 1dvp |SIZE=350|CAPTION= <scene name='initialview01'>1dvp</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1dvp", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1dvp| PDB=1dvp | SCENE= }}
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|RELATEDENTRY=[[1vfy|1VFY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dvp OCA], [http://www.ebi.ac.uk/pdbsum/1dvp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dvp RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION'''
'''CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION'''
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[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
[[Category: Wu, M N.]]
[[Category: Wu, M N.]]
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[[Category: fyve]]
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[[Category: Fyve]]
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[[Category: hr]]
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[[Category: Hr]]
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[[Category: superhelix]]
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[[Category: Superhelix]]
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[[Category: vh]]
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[[Category: Vh]]
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[[Category: zinc finger]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:20:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:49:40 2008''
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Revision as of 11:20, 2 May 2008

Image:1dvp.gif

Template:STRUCTURE 1dvp

CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION


Overview

We have determined the 2 A X-ray structure of the 219-residue N-terminal VHS and FYVE tandem domain unit of Drosophila Hrs. The unit assumes a pyramidal structure in which the much larger VHS domain (residues 1-153) forms a rectangular base and the FYVE domain occupies the apical end. The VHS domain is comprised of an unusual "superhelix" of eight alpha helices, and the FYVE domain is mainly built of loops, two double-stranded antiparallel sheets, and a helix stabilized by two tetrahedrally coordinated zinc atoms. The two-domain structure forms an exact 2-fold-related homodimer through antiparallel association of mainly FYVE domains. Dimerization creates two identical pockets designed for binding ligands with multiple negative charges such as citrate or phosphatidylinositol 3-phosphate.

About this Structure

1DVP is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction., Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen H, Quiocho FA, Cell. 2000 Feb 18;100(4):447-56. PMID:10693761 Page seeded by OCA on Fri May 2 14:20:21 2008

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