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1zj6

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Revision as of 09:19, 2 May 2018

Crystal structure of human ARL5

Structural highlights

1zj6 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ARL5A_HUMAN] Lacks ADP-ribosylation enhancing activity (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

ARL5 is a member of ARLs, which is widespread in high eukaryotes and homologous between species. But no structure or biological function of this member is reported. We expressed, purified, and resolved the structure of human ARL5 with bound GDP3'P at 2.0 A resolution. A comparison with the known structures of ARFs shows that besides the typical features of ARFs, human ARL5 has specific features of its own. Bacterially expressed human ARL5 contains bound GDP3'P which is seldom seen in other structures. The hydrophobic tail of the introduced detergent Triton X-305 binds at the possible myristoylation site of Gly2, simulating the myristoylated state of N-terminal amphipathic helix in vivo. The structural features of the nucleotide binding motifs and the switch regions prove that ARL5 will undergo the typical GDP/GTP structural cycle as other members of ARLs, which is the basis of their biological functions.

2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.,Wang ZX, Shi L, Liu JF, An XM, Chang WR, Liang DC Biochem Biophys Res Commun. 2005 Jul 8;332(3):640-5. PMID:15896705^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wang ZX, Shi L, Liu JF, An XM, Chang WR, Liang DC. 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. Biochem Biophys Res Commun. 2005 Jul 8;332(3):640-5. PMID:15896705 doi:10.1016/j.bbrc.2005.04.168

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zj6"

@@ Line 1: / Line 1: @@
 ==Crystal structure of human ARL5==
 <StructureSection load='1zj6' size='340' side='right' caption='[[1zj6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[1zj6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZJ6 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3D:GUANOSINE-3-MONOPHOSPHATE-5-DIPHOSPHATE'>G3D</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zj6 OCA], [http://pdbe.org/1zj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zj6 RCSB], [http://www.ebi.ac.uk/pdbsum/1zj6 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zj6 OCA], [http://pdbe.org/1zj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zj6 RCSB], [http://www.ebi.ac.uk/pdbsum/1zj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zj6 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/1zj6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/1zj6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

1zj6

From Proteopedia

Revision as of 09:19, 2 May 2018

Crystal structure of human ARL5

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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