1dwq

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[[Image:1dwq.jpg|left|200px]]
[[Image:1dwq.jpg|left|200px]]
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{{Structure
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|PDB= 1dwq |SIZE=350|CAPTION= <scene name='initialview01'>1dwq</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1dwq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ASA:Catalytic+Triad+Active+Site'>ASA</scene> and <scene name='pdbsite=ASB:Catalytic+Triad+Active+Site'>ASB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATO:CHLOROACETONE'>ATO</scene>, <scene name='pdbligand=CSA:S-ACETONYLCYSTEINE'>CSA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-epoxysuccinate_hydrolase Trans-epoxysuccinate hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.4 3.3.2.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1dwq| PDB=1dwq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwq OCA], [http://www.ebi.ac.uk/pdbsum/1dwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dwq RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH SUBSTRATES ACETONE AND CHLOROACETONE:IMPLICATIONS FOR THE MECHANISM OF CYANOGENESIS'''
'''CRYSTAL STRUCTURE OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH SUBSTRATES ACETONE AND CHLOROACETONE:IMPLICATIONS FOR THE MECHANISM OF CYANOGENESIS'''
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[[Category: Mielich, B.]]
[[Category: Mielich, B.]]
[[Category: Wajant, H.]]
[[Category: Wajant, H.]]
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[[Category: chloroacetone complex]]
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[[Category: Chloroacetone complex]]
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[[Category: hydroxynitrile lyase]]
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[[Category: Hydroxynitrile lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:22:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:50:18 2008''
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Revision as of 11:22, 2 May 2008

Image:1dwq.jpg

Template:STRUCTURE 1dwq

CRYSTAL STRUCTURE OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH SUBSTRATES ACETONE AND CHLOROACETONE:IMPLICATIONS FOR THE MECHANISM OF CYANOGENESIS


Overview

The crystal structures of hydroxynitrile lyase from Manihot esculenta (MeHNL) complexed with the native substrate acetone and substrate analogue chloroacetone have been determined and refined at 2.2 A resolution. The substrates are positioned in the active site by hydrogen-bond interactions of the carbonyl O atom with Thr11 OG, Ser80 OG and, to a lesser extent, Cys81 SG. These studies support a mechanism for cyanogenesis as well as for the stereospecific MeHNL-catalyzed formation of (S)-cyanohydrins, which closely resembles the base-catalyzed chemical reaction of HCN with carbonyl compounds.

About this Structure

1DWQ is a Single protein structure of sequence from Manihot esculenta. Full crystallographic information is available from OCA.

Reference

Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis., Lauble H, Forster S, Miehlich B, Wajant H, Effenberger F, Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):194-200. PMID:11173464 Page seeded by OCA on Fri May 2 14:22:22 2008

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