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2qif

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Revision as of 09:52, 18 October 2017

Crystal structure of a metallochaperone with a tetranuclear Cu(I) cluster

Structural highlights

2qif is a 2 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	1k0v, 1p8g
Gene:	copZ, yvgY (Bacillus subtilis)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[COPZ_BACSU] Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Copper trafficking proteins and copper-sensitive regulators are often found to be able to bind multiple Cu(I) ions in the form of Cu(I) clusters. We have determined the high-resolution X-ray crystal structure of an Atx1-like copper chaperone protein from Bacillus subtilis containing a novel tetranuclear Cu(I) cluster. The identities and oxidation states of the cluster ions were established unambiguously by refinement of X-ray energy-dependent anomalous scattering factors. The [Cu(4)(S-Cys)(4)(N-His)(2)] cluster geometry provides new structural insights into not only the binding of multiple cuprous ions by metallochaperones but also protein-associated tetranuclear Cu(I) clusters, including those found in eukaryotic copper-responsive transcription factors.

A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ.,Hearnshaw S, West C, Singleton C, Zhou L, Kihlken MA, Strange RW, Le Brun NE, Hemmings AM Biochemistry. 2009 Oct 13;48(40):9324-6. PMID:19746989^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hearnshaw S, West C, Singleton C, Zhou L, Kihlken MA, Strange RW, Le Brun NE, Hemmings AM. A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ. Biochemistry. 2009 Oct 13;48(40):9324-6. PMID:19746989 doi:10.1021/bi9011995

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qif"

@@ Line 1: / Line 1: @@
 ==Crystal structure of a metallochaperone with a tetranuclear Cu(I) cluster==
 <StructureSection load='2qif' size='340' side='right' caption='[[2qif]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k0v|1k0v]], [[1p8g|1p8g]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copZ, yvgY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copZ, yvgY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Bacillus subtilis])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qif OCA], [http://pdbe.org/2qif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qif RCSB], [http://www.ebi.ac.uk/pdbsum/2qif PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qif OCA], [http://pdbe.org/2qif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qif RCSB], [http://www.ebi.ac.uk/pdbsum/2qif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qif ProSAT]</span></td></tr>
 </table>
 == Function ==

2qif

From Proteopedia

Revision as of 09:52, 18 October 2017

Crystal structure of a metallochaperone with a tetranuclear Cu(I) cluster

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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