1dz9

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[[Image:1dz9.gif|left|200px]]
[[Image:1dz9.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dz9 |SIZE=350|CAPTION= <scene name='initialview01'>1dz9</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1dz9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=K1:This+Is+The+Intramolecular+K+Binding+Site+For+Monomer+A+...'>K1</scene>, <scene name='pdbsite=K2:This+Is+The+Intramolecular+K+Binding+Site+For+Monomer+B+...'>K2</scene>, <scene name='pdbsite=K3:Intermolecular+K+Site'>K3</scene> and <scene name='pdbsite=OXO:O'>OXO</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAM:CAMPHOR'>CAM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1dz9| PDB=1dz9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dz9 OCA], [http://www.ebi.ac.uk/pdbsum/1dz9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dz9 RCSB]</span>
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}}
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'''PUTATIVE OXO COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA'''
'''PUTATIVE OXO COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA'''
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[[Category: Stock, A M.]]
[[Category: Stock, A M.]]
[[Category: Sweet, R M.]]
[[Category: Sweet, R M.]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: mono-oxygenase]]
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[[Category: Mono-oxygenase]]
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[[Category: reaction intermediate]]
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[[Category: Reaction intermediate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:27:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:52 2008''
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Revision as of 11:27, 2 May 2008

Image:1dz9.gif

Template:STRUCTURE 1dz9

PUTATIVE OXO COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA


Overview

Members of the cytochrome P450 superfamily catalyze the addition of molecular oxygen to nonactivated hydrocarbons at physiological temperature-a reaction that requires high temperature to proceed in the absence of a catalyst. Structures were obtained for three intermediates in the hydroxylation reaction of camphor by P450cam with trapping techniques and cryocrystallography. The structure of the ferrous dioxygen adduct of P450cam was determined with 0.91 angstrom wavelength x-rays; irradiation with 1.5 angstrom x-rays results in breakdown of the dioxygen molecule to an intermediate that would be consistent with an oxyferryl species. The structures show conformational changes in several important residues and reveal a network of bound water molecules that may provide the protons needed for the reaction.

About this Structure

1DZ9 is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

The catalytic pathway of cytochrome p450cam at atomic resolution., Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG, Science. 2000 Mar 3;287(5458):1615-22. PMID:10698731 Page seeded by OCA on Fri May 2 14:27:44 2008

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OCA

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