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2ra1

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Revision as of 07:46, 25 October 2017

Crystal structure of the N-terminal part of the bacterial S-layer protein SbsC

Structural highlights

2ra1 is a 1 chain structure with sequence from Atcc 12980. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	sbsC (ATCC 12980)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Surface layers (S-layers) comprise the outermost cell envelope component of most archaea and many bacteria. Here we present the structure of the bacterial S-layer protein SbsC from Geobacillus stearothermophilus, showing a very elongated and flexible molecule, with strong and specific binding to the secondary cell wall polymer (SCWP). The crystal structure of rSbsC((31-844)) revealed a novel fold, consisting of six separate domains, which are connected by short flexible linkers. The N-terminal domain exhibits positively charged residues regularly spaced along the putative ligand binding site matching the distance of the negative charges on the extended SCWP. Upon SCWP binding, a considerable stabilization of the N-terminal domain occurs. These findings provide insight into the processes of S-layer attachment to the underlying cell wall and self-assembly, and also accommodate the observed mechanical strength, the polarity of the S-layer, and the pronounced requirement for surface flexibility inherent to cell growth and division.

The structure and binding behavior of the bacterial cell surface layer protein SbsC.,Pavkov T, Egelseer EM, Tesarz M, Svergun DI, Sleytr UB, Keller W Structure. 2008 Aug 6;16(8):1226-37. PMID:18682224^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pavkov T, Egelseer EM, Tesarz M, Svergun DI, Sleytr UB, Keller W. The structure and binding behavior of the bacterial cell surface layer protein SbsC. Structure. 2008 Aug 6;16(8):1226-37. PMID:18682224 doi:10.1016/j.str.2008.05.012

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ra1"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the N-terminal part of the bacterial S-layer protein SbsC==
 <StructureSection load='2ra1' size='340' side='right' caption='[[2ra1]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[2ra1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RA1 FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sbsC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ra1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra1 OCA], [http://pdbe.org/2ra1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ra1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ra1 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ra1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra1 OCA], [http://pdbe.org/2ra1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ra1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ra1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ra1 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

2ra1

From Proteopedia

Revision as of 07:46, 25 October 2017

Crystal structure of the N-terminal part of the bacterial S-layer protein SbsC

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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