1e4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1e4u.gif|left|200px]]
[[Image:1e4u.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1e4u |SIZE=350|CAPTION= <scene name='initialview01'>1e4u</scene>
+
The line below this paragraph, containing "STRUCTURE_1e4u", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1e4u| PDB=1e4u | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e4u OCA], [http://www.ebi.ac.uk/pdbsum/1e4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e4u RCSB]</span>
+
-
}}
+
'''N-TERMINAL RING FINGER DOMAIN OF HUMAN NOT-4'''
'''N-TERMINAL RING FINGER DOMAIN OF HUMAN NOT-4'''
Line 31: Line 28:
[[Category: Timmers, H Th M.]]
[[Category: Timmers, H Th M.]]
[[Category: Vliet, P C.Van Der.]]
[[Category: Vliet, P C.Van Der.]]
-
[[Category: transcriptional control]]
+
[[Category: Transcriptional control]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:39:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:55:08 2008''
+

Revision as of 11:39, 2 May 2008

Image:1e4u.gif

Template:STRUCTURE 1e4u

N-TERMINAL RING FINGER DOMAIN OF HUMAN NOT-4


Overview

The NOT4 protein is a component of the CCR4.NOT complex, a global regulator of RNA polymerase II transcription. Human NOT4 (hNOT4) contains a RING finger motif of the C(4)C(4) type. We expressed and purified the N-terminal region of hNOT4 (residues 1-78) encompassing the RING finger motif and determined the solution structure by heteronuclear NMR. NMR experiments using a (113)Cd-substituted hNOT4 RING finger showed that two metal ions are bound through cysteine residues in a cross-brace manner. The three-dimensional structure of the hNOT4 RING finger was refined with root mean square deviation values of 0.58 +/- 0.13 A for the backbone atoms and 1.08 +/- 0.12 A for heavy atoms. The hNOT4 RING finger consists of an alpha-helix and three long loops that are stabilized by zinc coordination. The overall folding of the hNOT4 RING finger is similar to that of the C(3)HC(4) RING fingers. The relative orientation of the two zinc-chelating loops and the alpha-helix is well conserved. However, for the other regions, the secondary structural elements are distinct.

About this Structure

1E4U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers., Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R, J Biol Chem. 2001 Mar 30;276(13):10185-90. Epub 2000 Nov 21. PMID:11087754 Page seeded by OCA on Fri May 2 14:39:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e4u"
Personal tools