This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3gbk
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist== | ==Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist== | ||
<StructureSection load='3gbk' size='340' side='right' caption='[[3gbk]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3gbk' size='340' side='right' caption='[[3gbk]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PQ:2-[(1-{3-[4-(BIPHENYL-4-YLCARBONYL)-2-PROPYLPHENOXY]PROPYL}-1,2,3,4-TETRAHYDROQUINOLIN-5-YL)OXY]-2-METHYLPROPANOIC+ACID'>2PQ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PQ:2-[(1-{3-[4-(BIPHENYL-4-YLCARBONYL)-2-PROPYLPHENOXY]PROPYL}-1,2,3,4-TETRAHYDROQUINOLIN-5-YL)OXY]-2-METHYLPROPANOIC+ACID'>2PQ</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPAR gamma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPAR gamma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbk OCA], [http://pdbe.org/3gbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbk RCSB], [http://www.ebi.ac.uk/pdbsum/3gbk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbk OCA], [http://pdbe.org/3gbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbk RCSB], [http://www.ebi.ac.uk/pdbsum/3gbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbk ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 15: | Line 16: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbk_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbk_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 43: | Line 44: | ||
[[Category: Wu, S Y]] | [[Category: Wu, S Y]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Diabetes mellitus]] | [[Category: Diabetes mellitus]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
| Line 51: | Line 53: | ||
[[Category: Obesity]] | [[Category: Obesity]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Ppar aganist]] | [[Category: Ppar aganist]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
| Line 59: | Line 62: | ||
[[Category: Type ii diabetes]] | [[Category: Type ii diabetes]] | ||
[[Category: X-ray co-crystal analysis]] | [[Category: X-ray co-crystal analysis]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 06:01, 7 December 2018
Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist
| |||||||||||
Categories: Human | Hsieh, H P | Lin, C H | Peng, Y H | Wu, S Y | Activator | Alternative splicing | Diabetes mellitus | Disease mutation | Dna-binding | Ligand binding protein | Metal-binding | Nucleus | Obesity | Phosphoprotein | Polymorphism | Ppar aganist | Receptor | Selective | Structure-based drug design | Transcription | Transcription regulation | Type ii diabetes | X-ray co-crystal analysis | Zinc | Zinc-finger
