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3dng
From Proteopedia
(Difference between revisions)
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==Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor== | ==Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor== | ||
<StructureSection load='3dng' size='340' side='right' caption='[[3dng]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3dng' size='340' side='right' caption='[[3dng]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
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<table><tr><td colspan='2'>[[3dng]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DNG FirstGlance]. <br> | <table><tr><td colspan='2'>[[3dng]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DNG FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AXA:(5S)-5-(2-AMINO-2-OXOETHYL)-4-OXO-N-[(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL)METHYL]-3,4,5,6,7,8-HEXAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE-2-CARBOXAMIDE'>AXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AXA:(5S)-5-(2-AMINO-2-OXOETHYL)-4-OXO-N-[(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL)METHYL]-3,4,5,6,7,8-HEXAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE-2-CARBOXAMIDE'>AXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xuc|1xuc]], [[1xud|1xud]], [[1xur|1xur]], [[2ow9|2ow9]], [[2ozr|2ozr]], [[1utt|1utt]], [[1utz|1utz]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP8, CLG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP8, CLG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dng OCA], [http://pdbe.org/3dng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dng RCSB], [http://www.ebi.ac.uk/pdbsum/3dng PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dng OCA], [http://pdbe.org/3dng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dng RCSB], [http://www.ebi.ac.uk/pdbsum/3dng PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dng ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/3dng_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/3dng_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3dng" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3dng" style="background-color:#fffaf0;"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Matrix metalloproteinase|Matrix metalloproteinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Montanari, R]] | [[Category: Montanari, R]] | ||
[[Category: Pochetti, G]] | [[Category: Pochetti, G]] | ||
| + | [[Category: Calcium]] | ||
[[Category: Collagen degradation]] | [[Category: Collagen degradation]] | ||
[[Category: Extracellular matrix]] | [[Category: Extracellular matrix]] | ||
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[[Category: Metalloprotease]] | [[Category: Metalloprotease]] | ||
[[Category: Non-zinc chelating inhibitor]] | [[Category: Non-zinc chelating inhibitor]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Selective inhibition]] | [[Category: Selective inhibition]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 07:19, 13 December 2017
Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor
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Categories: Human | Neutrophil collagenase | Mazza, F | Montanari, R | Pochetti, G | Calcium | Collagen degradation | Extracellular matrix | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Non-zinc chelating inhibitor | Polymorphism | Protease | Secreted | Selective inhibition | Zinc | Zymogen
