1e5t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1e5t.jpg|left|200px]]
[[Image:1e5t.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1e5t |SIZE=350|CAPTION= <scene name='initialview01'>1e5t</scene>, resolution 1.7&Aring;
+
The line below this paragraph, containing "STRUCTURE_1e5t", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AS:Active+Site,+Catalytic+Triad'>AS</scene> and <scene name='pdbsite=SS:Disulfide+Engineered+Between+Cys78+And+Gln397cys'>SS</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1e5t| PDB=1e5t | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5t OCA], [http://www.ebi.ac.uk/pdbsum/1e5t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e5t RCSB]</span>
+
-
}}
+
'''PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT'''
'''PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT'''
Line 27: Line 24:
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Fulop, V.]]
[[Category: Fulop, V.]]
-
[[Category: alpha/ beta-hydrolase]]
+
[[Category: Alpha/ beta-hydrolase]]
-
[[Category: amnesia]]
+
[[Category: Amnesia]]
-
[[Category: beta-propeller]]
+
[[Category: Beta-propeller]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: prolyl oligopeptidase]]
+
[[Category: Prolyl oligopeptidase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:42:07 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:55:44 2008''
+

Revision as of 11:42, 2 May 2008

Image:1e5t.jpg

Template:STRUCTURE 1e5t

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT


Overview

Proteases have a variety of strategies for selecting substrates in order to prevent uncontrolled protein degradation. A recent crystal structure determination of prolyl oligopeptidase has suggested a way for substrate selection involving an unclosed seven-bladed beta-propeller domain. We have engineered a disulfide bond between the first and seventh blades of the propeller, which resulted in the loss of enzymatic activity. These results provided direct evidence for a novel strategy of regulation in which oscillating propeller blades act as a gating filter during catalysis, letting small peptide substrates into the active site while excluding large proteins to prevent accidental proteolysis.

About this Structure

1E5T is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Catalysis of serine oligopeptidases is controlled by a gating filter mechanism., Fulop V, Szeltner Z, Polgar L, EMBO Rep. 2000 Sep;1(3):277-81. PMID:11256612 Page seeded by OCA on Fri May 2 14:42:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e5t"
Personal tools