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3go5

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Revision as of 07:08, 1 November 2017

Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution

Structural highlights

3go5 is a 1 chain structure with sequence from Strpn. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Gene:	NP_345429.1, SP_0946 (STRPN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus. We show here that CvfB binds RNA. The crystal structure of the CvfB ortholog from Streptococcus pneumoniae at 1.4 A resolution reveals a unique RNA binding protein that is formed from a concatenation of well-known structural modules that bind nucleic acids: three consecutive S1 RNA binding domains and a winged helix (WH) domain. The third S1 and the WH domains are required for cooperative RNA binding and form a continuous surface that likely contributes to the RNA interaction. The WH domain is critical to CvfB function and contains a unique sequence motif. Thus CvfB represents a novel assembly of modules for binding RNA.

Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.,Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA Structure. 2010 Mar 14;18(4):537-47. PMID:20399190^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Structure. 2010 Mar 14;18(4):537-47. PMID:20399190 doi:10.1016/j.str.2010.02.007

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3go5"

@@ Line 1: / Line 1: @@
 ==Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution==
 <StructureSection load='3go5' size='340' side='right' caption='[[3go5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP_345429.1, SP_0946 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3go5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3go5 OCA], [http://pdbe.org/3go5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3go5 RCSB], [http://www.ebi.ac.uk/pdbsum/3go5 PDBsum], [http://www.topsan.org/Proteins/JCSG/3go5 TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3go5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3go5 OCA], [http://pdbe.org/3go5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3go5 RCSB], [http://www.ebi.ac.uk/pdbsum/3go5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3go5 ProSAT], [http://www.topsan.org/Proteins/JCSG/3go5 TOPSAN]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

3go5

From Proteopedia

Revision as of 07:08, 1 November 2017

Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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