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2jju

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Revision as of 06:59, 11 July 2018

Structure of human signal regulatory protein (sirp) beta

Structural highlights

2jju is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	2jjv, 2jjw, 2uv3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SIRB1_HUMAN] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells. We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresponding regions in SIRPalpha. We have also determined structures of the N-terminal domains of SIRPbeta, SIRPbeta(2), and SIRPgamma; proteins that are closely related to SIRPalpha but bind CD47 with negligible or reduced affinity. These results explain the specificity of CD47 for the SIRP family of paired receptors in atomic detail. Analysis of SIRPalpha polymorphisms suggests that these, as well as the activating SIRPs, may have evolved to counteract pathogen binding to the inhibitory SIRPalpha receptor.

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.,Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:10.1016/j.molcel.2008.05.026

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jju"

@@ Line 1: / Line 1: @@
-==STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA==
+==Structure of human signal regulatory protein (sirp) beta==
 <StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
 == Structural highlights ==
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jjv|2jjv]], [[2jjw|2jjw]], [[2uv3|2uv3]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://pdbe.org/2jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://pdbe.org/2jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 13: / Line 14: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jju_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jju_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 39: / Line 40: @@
 [[Category: Stuart, D I]]
 [[Category: Turner, J]]
+[[Category: Alternative splicing]]
 [[Category: Glycoprotein]]
 [[Category: Immune system]]
@@ Line 45: / Line 47: @@
 [[Category: Membrane]]
 [[Category: Paired receptor]]
+[[Category: Polymorphism]]
 [[Category: Signal regulatory protein beta]]
 [[Category: Sirp]]
 [[Category: Sirpb1]]
 [[Category: Transmembrane]]

2jju

From Proteopedia

Revision as of 06:59, 11 July 2018

Structure of human signal regulatory protein (sirp) beta

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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