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1ebu

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[[Image:1ebu.jpg|left|200px]]
[[Image:1ebu.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ebu |SIZE=350|CAPTION= <scene name='initialview01'>1ebu</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1ebu", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDA:3-AMINOMETHYL-PYRIDINIUM-ADENINE-DINUCLEOTIDE'>NDA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_dehydrogenase Homoserine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.3 1.1.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HOM6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1ebu| PDB=1ebu | SCENE= }}
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|RELATEDENTRY=[[1ebf|1EBF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ebu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ebu OCA], [http://www.ebi.ac.uk/pdbsum/1ebu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ebu RCSB]</span>
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}}
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'''HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE'''
'''HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE'''
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[[Category: Thompson, P R.]]
[[Category: Thompson, P R.]]
[[Category: Wright, G D.]]
[[Category: Wright, G D.]]
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[[Category: analogue]]
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[[Category: Analogue]]
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[[Category: dehydrogenase]]
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[[Category: Dehydrogenase]]
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[[Category: dinucleotide]]
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[[Category: Dinucleotide]]
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[[Category: homoserine]]
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[[Category: Homoserine]]
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[[Category: ternary]]
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[[Category: Ternary]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:54:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:59:25 2008''
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Revision as of 11:54, 2 May 2008

Image:1ebu.jpg

Template:STRUCTURE 1ebu

HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE


Overview

The structure of the antifungal drug target homoserine dehydrogenase (HSD) was determined from Saccharomyces cerevisiae in apo and holo forms, and as a ternary complex with bound products, by X-ray diffraction. The three forms show that the enzyme is a dimer, with each monomer composed of three regions, the nucleotide-binding region, the dimerization region and the catalytic region. The dimerization and catalytic regions have novel folds, whereas the fold of the nucleotide-binding region is a variation on the Rossmann fold. The novel folds impose a novel composition and arrangement of active site residues when compared to all other currently known oxidoreductases. This observation, in conjunction with site-directed mutagenesis of active site residues and steady-state kinetic measurements, suggest that HSD exhibits a new variation on dehydrogenase chemistry.

About this Structure

1EBU is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases., DeLaBarre B, Thompson PR, Wright GD, Berghuis AM, Nat Struct Biol. 2000 Mar;7(3):238-44. PMID:10700284 Page seeded by OCA on Fri May 2 14:54:58 2008

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