1ed1

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[[Image:1ed1.gif|left|200px]]
[[Image:1ed1.gif|left|200px]]
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{{Structure
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|PDB= 1ed1 |SIZE=350|CAPTION= <scene name='initialview01'>1ed1</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1ed1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>
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|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Simian immunodeficiency virus - mac])
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{{STRUCTURE_1ed1| PDB=1ed1 | SCENE= }}
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|RELATEDENTRY=[[1ecw|1ECW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ed1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed1 OCA], [http://www.ebi.ac.uk/pdbsum/1ed1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ed1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''
'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''
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[[Category: Roy, P.]]
[[Category: Roy, P.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: trimeric association]]
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[[Category: Trimeric association]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:57:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:11 2008''
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Revision as of 11:57, 2 May 2008

Image:1ed1.gif

Template:STRUCTURE 1ed1

CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.


Overview

Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.

About this Structure

1ED1 is a Single protein structure of sequence from Simian immunodeficiency virus - mac. Full crystallographic information is available from OCA.

Reference

Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025 Page seeded by OCA on Fri May 2 14:57:05 2008

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