1edr

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[[Image:1edr.gif|left|200px]]
[[Image:1edr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1edr |SIZE=350|CAPTION= <scene name='initialview01'>1edr</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1edr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A47:N6-METHOXY+ADENOSINE+5&#39;-MONOPHOSPHATE'>A47</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1edr| PDB=1edr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1edr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edr OCA], [http://www.ebi.ac.uk/pdbsum/1edr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1edr RCSB]</span>
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}}
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'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO6AATTCGCG) AT 1.6 ANGSTROM'''
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO6AATTCGCG) AT 1.6 ANGSTROM'''
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==About this Structure==
==About this Structure==
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1EDR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDR OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDR OCA].
==Reference==
==Reference==
Crystallographic studies on damaged DNAs. II. N(6)-methoxyadenine can present two alternate faces for Watson-Crick base-pairing, leading to pyrimidine transition mutagenesis., Chatake T, Hikima T, Ono A, Ueno Y, Matsuda A, Takenaka A, J Mol Biol. 1999 Dec 17;294(5):1223-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600380 10600380]
Crystallographic studies on damaged DNAs. II. N(6)-methoxyadenine can present two alternate faces for Watson-Crick base-pairing, leading to pyrimidine transition mutagenesis., Chatake T, Hikima T, Ono A, Ueno Y, Matsuda A, Takenaka A, J Mol Biol. 1999 Dec 17;294(5):1223-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600380 10600380]
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[[Category: Protein complex]]
 
[[Category: Chatake, T.]]
[[Category: Chatake, T.]]
[[Category: Hikima, T.]]
[[Category: Hikima, T.]]
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[[Category: Takenaka, A.]]
[[Category: Takenaka, A.]]
[[Category: Ueno, Y.]]
[[Category: Ueno, Y.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: damaged dna]]
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[[Category: Damaged dna]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: methoxyadenosine]]
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[[Category: Methoxyadenosine]]
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[[Category: modified nucleotide]]
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[[Category: Modified nucleotide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:58:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:27 2008''
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Revision as of 11:58, 2 May 2008

Image:1edr.gif

Template:STRUCTURE 1edr

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO6AATTCGCG) AT 1.6 ANGSTROM


Overview

In a previous paper, 2'-deoxy-N(6)-methoxyadenosine (mo(6)A) was shown to form a mismatch base-pair with 2'-deoxycytidine with a Watson-Crick-type geometry. To fully understand the structural basis of genetic mutations with damaged DNA, it is necessary to examine whether the methoxylated adenine residue still has the ability to form the regular Watson-Crick pairing with a thymine residue. Therefore, a DNA dodecamer with the sequence d(CGCGmo(6)AATTCGCG) has been synthesized and its crystal structure determined. The methoxylation has no significant effect on the overall DNA conformation, which is that of a standard B-form duplex. The methoxylated adenine moieties adopt the amino tautomer with an anti conformation around the C(6)-N(6) bond to the N(1) atom, and they form a Watson-Crick base-pair with thymine residues on the opposite strand, similar to an unmodified adenine residue. It is concluded that methoxylated adenine can present two alternate faces for base-pairing, thanks to the amino<-->imino tautomerism allowed by methoxylation. Based on this property, two gene transition routes are proposed.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystallographic studies on damaged DNAs. II. N(6)-methoxyadenine can present two alternate faces for Watson-Crick base-pairing, leading to pyrimidine transition mutagenesis., Chatake T, Hikima T, Ono A, Ueno Y, Matsuda A, Takenaka A, J Mol Biol. 1999 Dec 17;294(5):1223-30. PMID:10600380 Page seeded by OCA on Fri May 2 14:58:24 2008

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