1ex8

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==CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR==
==CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR==
<StructureSection load='1ex8' size='340' side='right' caption='[[1ex8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='1ex8' size='340' side='right' caption='[[1ex8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hka|1hka]], [[1eqm|1eqm]], [[1eq0|1eq0]], [[1eqo|1eqo]], [[1cbk|1cbk]], [[1dy3|1dy3]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hka|1hka]], [[1eqm|1eqm]], [[1eq0|1eq0]], [[1eqo|1eqo]], [[1cbk|1cbk]], [[1dy3|1dy3]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex8 OCA], [http://pdbe.org/1ex8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ex8 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex8 OCA], [http://pdbe.org/1ex8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ex8 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex8 ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1ex8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1ex8" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase|6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase]]
 
== References ==
== References ==
<references/>
<references/>
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[[Category: Active-site architecture]]
[[Category: Active-site architecture]]
[[Category: Antimicrobial agent]]
[[Category: Antimicrobial agent]]
 +
[[Category: Atp]]
[[Category: Bisubstrate-mimicking inhibitor]]
[[Category: Bisubstrate-mimicking inhibitor]]
[[Category: Drug design]]
[[Category: Drug design]]

Revision as of 07:07, 20 December 2017

CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR

1ex8, resolution 1.85Å

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