1eg7

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[[Image:1eg7.jpg|left|200px]]
[[Image:1eg7.jpg|left|200px]]
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{{Structure
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|PDB= 1eg7 |SIZE=350|CAPTION= <scene name='initialview01'>1eg7</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1eg7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span>
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{{STRUCTURE_1eg7| PDB=1eg7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eg7 OCA], [http://www.ebi.ac.uk/pdbsum/1eg7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eg7 RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF FORMYLTETRAHYDROFOLATE SYNTHETASE FROM MOORELLA THERMOACETICA'''
'''THE CRYSTAL STRUCTURE OF FORMYLTETRAHYDROFOLATE SYNTHETASE FROM MOORELLA THERMOACETICA'''
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[[Category: Sheldrick, G M.]]
[[Category: Sheldrick, G M.]]
[[Category: Shin, R.]]
[[Category: Shin, R.]]
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[[Category: atp binding]]
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[[Category: Atp binding]]
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[[Category: folate binding]]
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[[Category: Folate binding]]
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[[Category: formate binding]]
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[[Category: Formate binding]]
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[[Category: monovalent cation binding]]
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[[Category: Monovalent cation binding]]
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[[Category: synthetase]]
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[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:03:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:01:56 2008''
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Revision as of 12:03, 2 May 2008

Image:1eg7.jpg

Template:STRUCTURE 1eg7

THE CRYSTAL STRUCTURE OF FORMYLTETRAHYDROFOLATE SYNTHETASE FROM MOORELLA THERMOACETICA


Overview

The structure was solved at 2.5 A resolution using multiwavelength anomalous dispersion (MAD) scattering by Se-Met residues. The subunit of N(10)-formyltetrahydrofolate synthetase is composed of three domains organized around three mixed beta-sheets. There are two cavities between adjacent domains. One of them was identified as the nucleotide binding site by homology modeling. The large domain contains a seven-stranded beta-sheet surrounded by helices on both sides. The second domain contains a five-stranded beta-sheet with two alpha-helices packed on one side while the other two are a wall of the active site cavity. The third domain contains a four-stranded beta-sheet forming a half-barrel. The concave side is covered by two helices while the convex side is another wall of the large cavity. Arg 97 is likely involved in formyl phosphate binding. The tetrameric molecule is relatively flat with the shape of the letter X, and the active sites are located at the end of the subunits far from the subunit interface.

About this Structure

1EG7 is a Single protein structure of sequence from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica., Radfar R, Shin R, Sheldrick GM, Minor W, Lovell CR, Odom JD, Dunlap RB, Lebioda L, Biochemistry. 2000 Apr 11;39(14):3920-6. PMID:10747779 Page seeded by OCA on Fri May 2 15:03:47 2008

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