1eiz

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[[Image:1eiz.jpg|left|200px]]
[[Image:1eiz.jpg|left|200px]]
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{{Structure
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|PDB= 1eiz |SIZE=350|CAPTION= <scene name='initialview01'>1eiz</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1eiz", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1eiz| PDB=1eiz | SCENE= }}
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|RELATEDENTRY=[[1ej0|1EJ0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eiz OCA], [http://www.ebi.ac.uk/pdbsum/1eiz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eiz RCSB]</span>
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}}
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'''FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE'''
'''FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE'''
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[[Category: Zheng, F.]]
[[Category: Zheng, F.]]
[[Category: 23s ribosomal rna]]
[[Category: 23s ribosomal rna]]
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[[Category: adenosyl methionine]]
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[[Category: Adenosyl methionine]]
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[[Category: adomet]]
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[[Category: Adomet]]
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[[Category: ftsj]]
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[[Category: Ftsj]]
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[[Category: heat shock protein]]
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[[Category: Heat shock protein]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:09:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:03:29 2008''
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Revision as of 12:09, 2 May 2008

Image:1eiz.jpg

Template:STRUCTURE 1eiz

FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE


Overview

Structural, biochemical, and genetic techniques were applied to investigate the function of FtsJ, a recently identified heat shock protein. FtsJ is well conserved, from bacteria to humans. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. The molecular surface of FtsJ exposes a putative nucleic acid binding groove composed of highly conserved, positively charged residues. Substrate analysis showed that FtsJ methylates 23S rRNA within 50S ribosomal subunits in vitro and in vivo. Null mutations in ftsJ show a dramatically altered ribosome profile, a severe growth disadvantage, and a temperature-sensitive phenotype. Our results reveal an unexpected link between the heat shock response and RNA metabolism.

About this Structure

1EIZ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

RNA methylation under heat shock control., Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U, Mol Cell. 2000 Aug;6(2):349-60. PMID:10983982 Page seeded by OCA on Fri May 2 15:09:25 2008

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OCA

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