1ek0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ek0.jpg|left|200px]]
[[Image:1ek0.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ek0 |SIZE=350|CAPTION= <scene name='initialview01'>1ek0</scene>, resolution 1.48&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ek0", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MHO:S-OXYMETHIONINE'>MHO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ek0| PDB=1ek0 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ek0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ek0 OCA], [http://www.ebi.ac.uk/pdbsum/1ek0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ek0 RCSB]</span>
+
-
}}
+
'''GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION'''
'''GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION'''
Line 27: Line 24:
[[Category: Esters, H.]]
[[Category: Esters, H.]]
[[Category: Scheidig, A J.]]
[[Category: Scheidig, A J.]]
-
[[Category: endocytosis]]
+
[[Category: Endocytosis]]
-
[[Category: g protein]]
+
[[Category: G protein]]
-
[[Category: gtp hydrolysis]]
+
[[Category: Gtp hydrolysis]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: vesicular traffic]]
+
[[Category: Vesicular traffic]]
-
[[Category: ypt/rab protein]]
+
[[Category: Ypt/rab protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:11:51 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:04:09 2008''
+

Revision as of 12:11, 2 May 2008

Image:1ek0.jpg

Template:STRUCTURE 1ek0

GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION


Overview

Ypt/Rab proteins are membrane-associated small GTP-binding proteins which play a central role in the coordination, activation and regulation of vesicle-mediated transport in eukaryotic cells. We present the 1.5 A high-resolution crystal structure of Ypt51 in its active, GppNHp-bound conformation. Ypt51 is an important regulator involved in the endocytic membrane traffic of Saccharomyces cerevisiae. The structure reveals small but significant structural differences compared with H-Ras p21. The effector loop and the catalytic loop are well defined and stabilized by extensive hydrophobic interactions. The switch I and switch II regions form a well-defined epitope for hypothetical effector protein binding. Sequence comparisons between the different isoforms Ypt51, Ypt52 and Ypt53 provide the first insights into determinants for specific effector binding and for fine-tuning of the intrinsic GTP-hydrolysis rate.

About this Structure

1EK0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis., Esters H, Alexandrov K, Constantinescu AT, Goody RS, Scheidig AJ, J Mol Biol. 2000 Apr 21;298(1):111-21. PMID:10756108 Page seeded by OCA on Fri May 2 15:11:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ek0"
Personal tools