This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1pls

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 06:52, 29 November 2017

SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN

Structural highlights

1pls is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	CDNA (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PLEK_HUMAN] Major protein kinase C substrate of platelets.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Pleckstrin, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins. These conserved sequences, termed pleckstrin-homology (PH) domains, are thought to be involved in signal transduction. But the details of the function and binding partners of the PH domains have not been characterized. Here we report the solution structure of the N-terminal pleckstrin-homology domain of pleckstrin determined using heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. The structure consists of an up-and-down beta-barrel of seven antiparallel beta-strands and a C-terminal amphiphilic alpha-helix that caps one end of the barrel. The overall topology of the domain is similar to that of the retinol-binding protein family of structures.

Solution structure of a pleckstrin-homology domain.,Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW Nature. 1994 Jun 23;369(6482):672-5. PMID:8208296^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW. Solution structure of a pleckstrin-homology domain. Nature. 1994 Jun 23;369(6482):672-5. PMID:8208296 doi:http://dx.doi.org/10.1038/369672a0

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pls"

@@ Line 1: / Line 1: @@
 ==SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN==
 <StructureSection load='1pls' size='340' side='right' caption='[[1pls]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[1pls]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PLS FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pls OCA], [http://pdbe.org/1pls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pls RCSB], [http://www.ebi.ac.uk/pdbsum/1pls PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pls OCA], [http://pdbe.org/1pls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pls RCSB], [http://www.ebi.ac.uk/pdbsum/1pls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pls ProSAT]</span></td></tr>
 </table>
 == Function ==

1pls

From Proteopedia

Revision as of 06:52, 29 November 2017

SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox