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1elt

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[[Image:1elt.gif|left|200px]]
[[Image:1elt.gif|left|200px]]
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{{Structure
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|PDB= 1elt |SIZE=350|CAPTION= <scene name='initialview01'>1elt</scene>, resolution 1.61&Aring;
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The line below this paragraph, containing "STRUCTURE_1elt", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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{{STRUCTURE_1elt| PDB=1elt | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1elt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1elt OCA], [http://www.ebi.ac.uk/pdbsum/1elt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1elt RCSB]</span>
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'''STRUCTURE OF NATIVE PANCREATIC ELASTASE FROM NORTH ATLANTIC SALMON AT 1.61 ANGSTROMS RESOLUTION'''
'''STRUCTURE OF NATIVE PANCREATIC ELASTASE FROM NORTH ATLANTIC SALMON AT 1.61 ANGSTROMS RESOLUTION'''
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[[Category: Berglund, G I.]]
[[Category: Berglund, G I.]]
[[Category: Smalaas, A O.]]
[[Category: Smalaas, A O.]]
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[[Category: serine proteinase]]
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[[Category: Serine proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:15:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:05:08 2008''
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Revision as of 12:15, 2 May 2008

Image:1elt.gif

Template:STRUCTURE 1elt

STRUCTURE OF NATIVE PANCREATIC ELASTASE FROM NORTH ATLANTIC SALMON AT 1.61 ANGSTROMS RESOLUTION


Overview

The crystal structure of native salmon pancreatic elastase (SPE) has been solved by molecular-replacement methods, and refined by conventional conjugate-gradient methods and simulated-annealing techniques. The final R value is 17.2% for 21 389 reflections between 8.0 and 1.61 A, and the corresponding free R value is 23.9%. The overall tertiary structure of SPE is remarkably similar to that of porcine pancreatic elastase I (PPE), to which it shows about 67% sequence identity. The primary structure of SPE is determined from the electron-density maps, and only about 15 side chains are somewhat uncertain. Interesting differences between SPE and PPE, are one sequence deletion assigned to position 186, the residue 192 at the entrance of the specificity pocket is substituted from a Gln in PPE to Asn in SPE, and one of the calcium ligands is different. Furthermore, electron density is missing in SPE for the last three residues of the C-terminal helix. A comparison of the present amino-acid sequence of SPE with other sequences available indicates that SPE belongs to the class 1 pancreatic elastases.

About this Structure

1ELT is a Single protein structure of sequence from Salmo salar. Full crystallographic information is available from OCA.

Reference

Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution., Berglund GI, Willassen NP, Hordvik A, Smalas AO, Acta Crystallogr D Biol Crystallogr. 1995 Nov 1;51(Pt 6):925-37. PMID:15299762 Page seeded by OCA on Fri May 2 15:15:33 2008

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