1env
From Proteopedia
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'''ATOMIC STRUCTURE OF THE ECTODOMAIN FROM HIV-1 GP41''' | '''ATOMIC STRUCTURE OF THE ECTODOMAIN FROM HIV-1 GP41''' | ||
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[[Category: Weissenhorn, W.]] | [[Category: Weissenhorn, W.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
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| - | [[Category: | + | [[Category: Viral fusion]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:19:32 2008'' | |
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Revision as of 12:19, 2 May 2008
ATOMIC STRUCTURE OF THE ECTODOMAIN FROM HIV-1 GP41
Overview
Fusion of viral and cellular membranes by the envelope glycoprotein gp120/gp41 effects entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 and gp41 which remain non-covalently associated. Binding to both CD4 and a co-receptor leads to the conformational changes in gp120/gp41 needed for membrane fusion. We used X-ray crystallography to determine the structure of the protease-resistant part of a gp41 ectodomain solubilized with a trimeric GCN4 coiled coil in place of the amino-terminal fusion peptide. The core of the molecule is found to be an extended, triple-stranded alpha-helical coiled coil with the amino terminus at its tip. A carboxy-terminal alpha-helix packs in the reverse direction against the outside of the coiled coil, placing the amino and carboxy termini near each other at one end of the long rod. These features, and the existence of a similar reversal of chain direction in the fusion pH-induced conformation of influenza virus HA2 and in the transmembrane subunit of Moloney murine leukaemia virus (Fig. 1a-d), suggest a common mechanism for initiating fusion.
About this Structure
1ENV is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Atomic structure of the ectodomain from HIV-1 gp41., Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC, Nature. 1997 May 22;387(6631):426-30. PMID:9163431 Page seeded by OCA on Fri May 2 15:19:32 2008
