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1eo8

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[[Image:1eo8.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eo8 OCA], [http://www.ebi.ac.uk/pdbsum/1eo8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eo8 RCSB]</span>
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'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY'''
'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY'''
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[[Category: Knossow, M.]]
[[Category: Knossow, M.]]
[[Category: Skehel, J J.]]
[[Category: Skehel, J J.]]
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[[Category: complex (hemagglutinin/immmunoglobulin)]]
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[[Category: Hemagglutinin]]
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[[Category: hemagglutinin]]
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[[Category: Immune system complex]]
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[[Category: immune system complex]]
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[[Category: Immunoglobulin]]
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[[Category: immunoglobulin]]
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[[Category: Viral protein]]
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[[Category: viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:20:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:06:28 2008''
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Revision as of 12:20, 2 May 2008

Image:1eo8.gif

Template:STRUCTURE 1eo8

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY


Overview

The structure of a complex between the hemagglutinin of influenza virus and the Fab of a neutralizing antibody was determined by X-ray crystallography at 2.8 A resolution. This antibody and another which has only 56% sequence identity bind to the same epitope with very similar affinities and in the same orientation. One third of the interactions is conserved in the two complexes; a significant proportion of the interactions that differ are established by residues of the H3 complementarity-determining regions (CDR) which adopt distinct conformations in the two antibodies. This demonstrates that there is a definite flexibility in the selection of antibodies that bind to a given epitope, despite the high affinity of their complexes. This flexibility allows the humoral immune response to be redundant, a feature that may be useful in achieving longer lasting protection against evolving viral pathogens.

About this Structure

1EO8 is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural evidence for recognition of a single epitope by two distinct antibodies., Fleury D, Daniels RS, Skehel JJ, Knossow M, Bizebard T, Proteins. 2000 Sep 1;40(4):572-8. PMID:10899782 Page seeded by OCA on Fri May 2 15:20:14 2008

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