1epw

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[[Image:1epw.gif|left|200px]]
[[Image:1epw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1epw |SIZE=350|CAPTION= <scene name='initialview01'>1epw</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1epw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1epw| PDB=1epw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1epw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epw OCA], [http://www.ebi.ac.uk/pdbsum/1epw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1epw RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''
'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''
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[[Category: Eswaramoorthy, S.]]
[[Category: Eswaramoorthy, S.]]
[[Category: Swaminathan, S.]]
[[Category: Swaminathan, S.]]
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[[Category: botulinum]]
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[[Category: Botulinum]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: neurotoxin]]
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[[Category: Neurotoxin]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:23:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:07:27 2008''
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Revision as of 12:23, 2 May 2008

Image:1epw.gif

Template:STRUCTURE 1epw

CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B


Overview

Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.

About this Structure

1EPW is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256 Page seeded by OCA on Fri May 2 15:23:16 2008

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