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1eqd

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[[Image:1eqd.gif|left|200px]]
[[Image:1eqd.gif|left|200px]]
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{{Structure
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|PDB= 1eqd |SIZE=350|CAPTION= <scene name='initialview01'>1eqd</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1eqd", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEV:5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC+ACID+FERROUS+COMPLEX'>HEV</scene>
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{{STRUCTURE_1eqd| PDB=1eqd | SCENE= }}
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|RELATEDENTRY=[[1d3s|1D3S]], [[1erx|1ERX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eqd OCA], [http://www.ebi.ac.uk/pdbsum/1eqd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eqd RCSB]</span>
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'''CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN'''
'''CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN'''
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[[Category: Roberts, S A.]]
[[Category: Roberts, S A.]]
[[Category: Weichsel, A.]]
[[Category: Weichsel, A.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: cyanide]]
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[[Category: Cyanide]]
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[[Category: ferric heme]]
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[[Category: Ferric heme]]
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[[Category: lipocalin fold]]
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[[Category: Lipocalin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:24:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:07:41 2008''
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Revision as of 12:24, 2 May 2008

Image:1eqd.gif

Template:STRUCTURE 1eqd

CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN


Overview

The nitrophorins comprise an unusual family of proteins that use ferric (Fe(III)) heme to transport highly reactive nitric oxide (NO) from the salivary gland of a blood sucking bug to the victim, resulting in vasodilation and reduced blood coagulation. We have determined structures of nitrophorin 4 in complexes with H2O, cyanide and nitric oxide. These structures reveal a remarkable feature: the nitrophorins have a broadly open distal pocket in the absence of NO, but upon NO binding, three or more water molecules are expelled and two loops fold into the distal pocket, resulting in the packing of hydrophobic groups around the NO molecule and increased distortion of the heme. In this way, the protein apparently forms a 'hydrophobic trap' for the NO molecule. The structures are very accurate, ranging between 1.6 and 1.4 A resolutions.

About this Structure

1EQD is a Single protein structure of sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.

Reference

Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial., Weichsel A, Andersen JF, Roberts SA, Montfort WR, Nat Struct Biol. 2000 Jul;7(7):551-4. PMID:10876239 Page seeded by OCA on Fri May 2 15:24:25 2008

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