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1erk

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[[Image:1erk.gif|left|200px]]
[[Image:1erk.gif|left|200px]]
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{{Structure
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|GENE= ERK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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{{STRUCTURE_1erk| PDB=1erk | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1erk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1erk OCA], [http://www.ebi.ac.uk/pdbsum/1erk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1erk RCSB]</span>
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'''STRUCTURE OF SIGNAL-REGULATED KINASE'''
'''STRUCTURE OF SIGNAL-REGULATED KINASE'''
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[[Category: Goldsmith, E J.]]
[[Category: Goldsmith, E J.]]
[[Category: Harkins, P C.]]
[[Category: Harkins, P C.]]
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[[Category: atp-binding cell cycle]]
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[[Category: Atp-binding cell cycle]]
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[[Category: phosphorylation.]]
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[[Category: Phosphorylation.]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:12 2008''
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Revision as of 12:26, 2 May 2008

Image:1erk.gif

Template:STRUCTURE 1erk

STRUCTURE OF SIGNAL-REGULATED KINASE


Overview

The structure of the MAP kinase ERK2, a ubiquitous protein kinase target for regulation by Ras and Raf, has been solved in its unphosphorylated low-activity conformation to a resolution of 2.3 A. The two domains of unphosphorylated ERK2 are farther apart than in the active conformation of cAMP-dependent protein kinase and the peptide-binding site is blocked by tyrosine 185, one of the two residues that are phosphorylated in the active enzyme. Activation of ERK2 is thus likely to involve both global and local conformational changes.

About this Structure

1ERK is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution., Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ, Nature. 1994 Feb 24;367(6465):704-11. PMID:8107865 Page seeded by OCA on Fri May 2 15:26:19 2008

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