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3jya
From Proteopedia
(Difference between revisions)
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==Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors== | ==Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors== | ||
<StructureSection load='3jya' size='340' side='right' caption='[[3jya]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3jya' size='340' side='right' caption='[[3jya]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jya OCA], [http://pdbe.org/3jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jya RCSB], [http://www.ebi.ac.uk/pdbsum/3jya PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jya OCA], [http://pdbe.org/3jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jya RCSB], [http://www.ebi.ac.uk/pdbsum/3jya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jya ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jya_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jya_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
| + | [[Category: Cytoplasm]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Manganese]] | [[Category: Manganese]] | ||
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[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Pim-1]] | [[Category: Pim-1]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:55, 26 December 2018
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
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Categories: Human | Non-specific serine/threonine protein kinase | Stoll, V S | Alternative initiation | Atp-binding | Cell membrane | Cytoplasm | Kinase | Manganese | Membrane | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Pim-1 | Polymorphism | Proto-oncogene | Serine/threonine-protein kinase | Transferase
