1esf

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[[Image:1esf.gif|left|200px]]
[[Image:1esf.gif|left|200px]]
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{{Structure
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|PDB= 1esf |SIZE=350|CAPTION= <scene name='initialview01'>1esf</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1esf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CD1:Cd+2++Binding+Site+I'>CD1</scene> and <scene name='pdbsite=CD2:Cd+2++Binding+Site+II'>CD2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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{{STRUCTURE_1esf| PDB=1esf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1esf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esf OCA], [http://www.ebi.ac.uk/pdbsum/1esf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1esf RCSB]</span>
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}}
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'''STAPHYLOCOCCAL ENTEROTOXIN A'''
'''STAPHYLOCOCCAL ENTEROTOXIN A'''
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[[Category: Schad, E M.]]
[[Category: Schad, E M.]]
[[Category: Svensson, L A.]]
[[Category: Svensson, L A.]]
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[[Category: enterotoxin]]
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[[Category: Enterotoxin]]
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[[Category: staphylococcal enterotoxin type some]]
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[[Category: Staphylococcal enterotoxin type some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:41 2008''
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Revision as of 12:28, 2 May 2008

Image:1esf.gif

Template:STRUCTURE 1esf

STAPHYLOCOCCAL ENTEROTOXIN A


Overview

Staphylococcal enterotoxins are prototype superantigens characterized by their ability to bind to major histocompatibility complex (MHC) class II molecules and subsequently activate a large fraction of T-lymphocytes. The crystal structure of staphylococcal enterotoxin type A (SEA), a 27 kDa monomeric protein, was determined to 1.9 A resolution with an R-factor of 19.9% by multiple isomorphous replacement. SEA is a two domain protein composed of a beta-barrel and a beta-grasp motif demonstrating the same general structure as staphylococcal enterotoxins SEB and TSST-1. Unique for SEA, however, is a Zn2+ coordination site involved in MHC class II binding. Four amino acids including Ser1, His187, His225 and Asp227 were found to be involved in direct coordination of the metal ion. SEA is the first Zn2+ binding enterotoxin that has been structurally determined.

About this Structure

1ESF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:7628431 Page seeded by OCA on Fri May 2 15:28:03 2008

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OCA

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