We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1z0v

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 13:26, 12 October 2017

Crystal Structure of A. fulgidus Lon proteolytic domain

Structural highlights

1z0v is a 6 chain structure with sequence from Arcfl. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1z0t, 1z0g, 1z0e, 1z0b, 1z0c, 1z0w
Activity:	Endopeptidase La, with EC number 3.4.21.53
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LONB_ARCFU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Although macromolecular crystallography is rapidly becoming largely routine owing to advances in methods of data collection, structure solution and refinement, difficult cases are still common. To remind structural biologists about the kinds of crystallographic difficulties that might be encountered, case studies of several successfully completed structure determinations that utilized less than perfect crystals are discussed here. The structure of the proteolytic domain of Archaeoglobus fulgidus Lon was solved with crystals that contained superimposed orthorhombic and monoclinic lattices, a case not previously described for proteins. Another hexagonal crystal form of this protein exhibited an unusually high degree of non-isomorphism. Crystals of A. fulgidus Rio1 kinase exhibited both pseudosymmetry and twinning. Ways of identifying the observed phenomena and approaches to solving and refining macromolecular structures when only less than perfect crystals are available are discussed here.

Pathological crystallography: case studies of several unusual macromolecular crystals.,Dauter Z, Botos I, LaRonde-LeBlanc N, Wlodawer A Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):967-75. Epub 2005, Jun 24. PMID:15983420^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dauter Z, Botos I, LaRonde-LeBlanc N, Wlodawer A. Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):967-75. Epub 2005, Jun 24. PMID:15983420 doi:10.1107/S0907444905011285

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z0v"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of A. fulgidus Lon proteolytic domain==
 <StructureSection load='1z0v' size='340' side='right' caption='[[1z0v]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z0t|1z0t]], [[1z0g|1z0g]], [[1z0e|1z0e]], [[1z0b|1z0b]], [[1z0c|1z0c]], [[1z0w|1z0w]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0v OCA], [http://pdbe.org/1z0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z0v RCSB], [http://www.ebi.ac.uk/pdbsum/1z0v PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0v OCA], [http://pdbe.org/1z0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z0v RCSB], [http://www.ebi.ac.uk/pdbsum/1z0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0v ProSAT]</span></td></tr>
 </table>
 == Function ==

1z0v

From Proteopedia

Revision as of 13:26, 12 October 2017

Crystal Structure of A. fulgidus Lon proteolytic domain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox